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Bifidobacterium longum  lysate

CAS:96507-89-0

EINECS:306-168-4

Probiotic health benefits

As an important organism involved in the maintenance of the human gastrointestinal tract, B. longum is commonly used as a probiotic in various dairy products.Its presence has been associated with many health benefits including improving lactose tolerance and preventing diarrhea, food allergies, and colonization by pathogens.Some strains of B. longum were demonstrated to have an antioxidative effect by inhibiting linoleic acid peroxidation,a process that results in the creation of lipid hydroperoxides that decompose into highly reactive radicals associated with aging and age-related diseases.Additionally, B. longum can scavenge free radicals, lowering a person’s chance of atherosclerosis and stroke.The ability of B. longum to remove cholesterol from its environment by incorporating cholesterol into its membrane is thought to lower the serum cholesterol level in humans. B. longum may also bind and suppress resorption of bile acids,which also lowers serum cholesterol levels as bile salt replacement requires utilization of cholesterol within the body.B. longum supplementation was shown to significantly suppress tumor volume and incidence, although the exact mechanism is not clear. Since high colonic pH is thought to promote colorectal cancer, it is postulated that B. longum can inhibit colorectal cancer by producing bile acid and cholesterol metabolites that lower the intestinal pH.

Therapeutic uses

Cancer treatment

As an anaerobe, B. longum is able to localize and proliferate in the hypoxic regions of solid tumors when injected intravenously.It is proposed that by introducing genes into B. longum that generate anti-tumor enzymes, B. longum will be able to act as the vector in cancer gene therapy.B. longum is an ideal vector as its actions should remain tumor-specific, it is non-pathogenic, and it generally easily killed by antibiotics unlike other potential anaerobic vectors such as Salmonella or Clostridium.

Immune system regulation

Several studies indicate that B. longum has a positive effect on modulating the immune system. A strain of B. longum has been shown to reduce the symptoms of Japanese cedar pollinosis,while other strains have been shown to reduce the symptoms of influenza infection and fever in elderly persons.As well, the use of B. longum was shown to shorten the duration and minimize the severity of symptoms associated with the common cold with a similar effect to that of neuraminidase inhibitors for influenza.

Sensitive skin treatment

When applied topically, B. longum lysate was shown to provide an anti-inflammatory effect, preventing problems associated with skin sensitivity and reinforcing skin barrier function.

Pancreatic necrosis

Pancreatic necrosis if left untreated has an almost 100 percent fatality rate due to bacterial translocation. Bifidobacterium longum subspecies infantis has been found to have a wide spectrum of coverage against pathogenic organisms that translocate from the gastrointestinal tract thereby demonstrating therapeutic benefit in the management of pancreatic necrosis. The addition of other probiotic strains reduces pro-inflammatory cytokines and further suppressed bacterial overgrowth in the small intestine leading to a reduction in bacterial translocation.