1.  Quick Detail:

Product Name: Theophylline

Synonyms: Theophylline anhydrous; 1,3-dimethyl-3,4,5,7-tetrahydro-1H-purine-2,6-dione

CAS: 58-55-9

EINECS: 200-385-7

MF: C7H10N4O2

MW: 182.1799

Assay: 99%

Appearance: White powder

Density 1.62g/cm3

Melting point 270-274℃

Boiling point 390.1°C at 760 mmHg

Refractive index 1.737

Flash point 189.7°C

Water solubility 8.3 g/L (20℃)

Vapour Pressur 2.72E-06mmHg at 25°C

2.  Descriptions:

Theophylline, also known as 1,3-dimethylxanthine, is a methylxanthine drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine.

The main actions of theophylline involve:

relaxing bronchial smooth muscle

increasing heart muscle contractility and efficiency; as a positive inotropic

increasing heart rate: (positive chronotropic)

increasing blood pressure

increasing renal blood flow

anti-inflammatory effects

central nervous system stimulatory effect mainly on the medullary respiratory center.

The main therapeutic uses of theophylline are aimed at:

chronic obstructive pulmonary disease (COPD)

asthma

infant apnea

Blocks the action of adenosine, an inhibitor neurotransmitter that induces sleep, contracts the smooth muscles and relaxes the cardiac muscle.