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Description
Tetracaine (also known as amethocaine; trade name Pontocaine and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
tetracaine (inn, also known as amethocaine; trade name pontocaine. ametop and dicaine) is a potent local anesthetic of the ester group. it is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. it is on the world health organization's list of essential medicines, a list of the most important medication needed in a basic health system.
(1) in biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. tetracaine is an allosteric blocker of channel function. at low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
(2) tetracaine is the t in tac, a mixture of 5 to 12 per cent tetracaine, 5m(per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) , and 4 or 10 per cent hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.
Name: Tetracaine
CAS: 94-24-6
MF: C15H24N2O2
MW: 264.36
EINECS: 202-316-6
Package: 1KG foil bag; 25Kg drum
Applications
Tetracaine is a topical opththalmic anesthetic used to relieve the pain the skin and as an eye drops for minor eye operations. It prevents voltage-sensitive release of Ca2+ from sarcoplasmic reticulum and can be used as a spinal anesthetic.
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