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99.8% agomelatine/agomelatine powder 138112-76-2
Product Name: Agomelatine
CAS NO: 138112-76-2
Molecular Formula: C12H18N4O5S
Formula Weight: 330.3601
Appearance: White crystalline power
Assay: 99.0% Min
Agomelatine is a melatonergic antidepressant developed by the pharmaceutical company Servier. It is marketed for the treatment of major depressive disorder and has been reported to not produce discontinuation syndrome and have no sexual side effects compared to SSRIs, SNRIs and the older tricyclic antidepressants. Agomelatine may also have positive effects on sleep.
Function:
Agomelatine is a new antidepressant with selective agonist actions at melatonin receptors and selective antagonist action at serotonin 5HT-2C receptors.
It does not affect the uptake of serotonin, noradrenaline or dopamine.
Agomelatine can help regulate your'body clock' (circadian rhythm) with positive benefits on mood and sleepin depression Agomelatine is used in the treatment of depression or to help prevent depression returning, and isonly available with a doctor's prescription. The symptoms of depression vary from one person toanother, but commonly include persistent sadness, loss of interest in favourite activities, feelings of worthlessness, sleep problems, feeling of being slowed down, feelings of anxiety or changes in appetite and weight. Changes in your daily sleep and appetite patterns are examples of disturbances of your body clock that occur commonly indepression.
Analysis Test | Specification |
Description | white crystalline powder,odorless |
Solubility | Easily soluble in water, unsoluble in ethanol |
PH | 6.0~7.5 |
Solution clarity and color | solution should be clear and colorless |
Related substances | 5’CMP 0.3% Simple impurity Total other impurity |
Chloride | 0.05% |
Ammonium | 0.05% |
Fe | 0.01% |
Phosphate | 0.1% |
Loss on drying | ≤6.0% |
Heavy metals | 0.002% |
Arsenide | 0.0001% |
Bacterial Endotoxins | 0.3EU/mg |
Microbial Limit | Conforms |
Assay(on dried basis) | ≥98.0% |