Metronidazole

Chinese alias: 1- (2-hydroxyethyl) -2-methyl-5-nitroimidazole; 2-methyl-5-nitro-1H-imidazole-1-ethanol; 2- (2-methyl- 4-Nitro-1-imidazolyl) ethanol; metronidazole; metronidazole; nitrofurazone; metronidoxylazole; imidazolidan; metronidazole; nitrohydroxylazole; funatier; Metronidazole; Frege;

English name: metronidazole

English aliases: 2-methyl-5-nitroimidazole-1-ethanol; Eumin; Bexon; Klont; 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-; Metronidazole; Atrivyl; Clont; FLACYL; Klion; Meronidal; Thivazol

CAS number: 443-48-1

Molecular formula: C6H9N3O3

Molecular weight: 171.15400

Structural formula:

Accurate quality: 171.06400

PSA: 83.87000

LogP: 0.61520

Physical and chemical properties

Appearance and properties: white to slightly yellow crystalline powder

Density: 1.45 g / cm2

Melting point: 159-161 ° C (lit.)

Boiling point: 405.4ºC at 760 mmHg

Flash point: 199ºC

Refractive index: 1.612

Stability: stable. Not compatible with strong oxidants.

Storage conditions: 2-8ºC

Vapor pressure: 2.67E-07mmHg at 25 ° C

Milky white crystals were obtained from ethyl acetate, MP158-160 ° C. Slightly smelly, slightly bitter and salty. Soluble in water (1: 100), ethanol (1: 200), chloroform (1: 250), slightly soluble in ether, insoluble in dimethylformamide, soluble in inorganic acids. The pH of the saturated aqueous solution is about 5. Keep away from light. The carbamate is crystallized from methyl cyanide, MP 151-152 ° C. Hydrogenated succinate MP 109 ° C. Phosphate crystals, MP 237-238 ° C. Benzoate MP 102 ℃